Reverse Tolerance

Prompted by “How Marijuana Tolerance Builds Up — And How to Bring It Down”:

Respectfully trimming out unnecessary scientific details from the prompting piece for our purpose and your convenience here…

The latest research from cannabis neuroscientists uncovers the mechanism behind the tolerance for cannabis, and shows us that it doesn’t take long for the brain to return to complete normalcy. […]

This latest piece of research was a collaboration project between prestigious organization such as the Schizophrenia and Neuropharmacology Research Group of the Connecticut Healthcare System, Yale University School of Medicine, the New York University Langone Medical Center and the Harvard Medical School Massachusetts General Hospital.

The age-old problem with cannabis requires people to smoke or dab more after the first time. Unlike opiates, overdosing on cannabis is difficult and THC does not become toxic until it reaches incredibly high levels in the body, equivalent to eating pounds and pounds of pure active ingredient in one sitting. Though a smoker might need to consume successively consume more cannabis as time goes on, it does not spiral out of control; someone could smoke the same amount of weed everyday for their entire life and still get high. […]

Regardless of how much cannabis a person consumed, CB1 receptor expression still only took about two days to bounce back significantly after abstaining. After four weeks of abstinence, PET scans did not find a statistical difference between past smokers and the eternally sober. […]

Patients who suffer from PTSD or anxiety need to understand that even a short break of less than a week will significantly reduce their tolerance, and they should not consume as much the first time going back to it.

To minimize tolerance issues, new users minimize intake amount initially and slowly increase that amount as fit for them.

Electronic vaporization with precise temperature control is highly recommended, because a very small pinch of leafy cannabis material at a reasonably low temperature (e.g. 390 degrees F) likely suffices as a starting point for those psychedelic entrants, and carcinogens are avoided (leaving toluene as the only apparently relatively minor toxin).

For specific health effects at various temperatures, check out the useful table in “Tailoring Your High: Compounds in Cannabis, Properties and Boiling Points”.

Smoking is relatively terribly inefficient (so much more costly btw), and lacks those appreciated intake controls.

According to our state’s medical cannabis literature, there’s an intake amount so little (but obviously still medically useful), reverse tolerance buildup occurs — so it takes less cannabis to reach the same effect in consequent usage sessions.

I suspect excessive tolerance buildup mutes the many details of cannabis’ effects (e.g. the many terpene contributions, which I’ll be going into more detail in a soon-upcoming post fwiw and btw). However, there’s no concrete evidence to support that ‘effect muting’ hypothesis (just suggestive anecdotal evidence).

Tolerance is thankfully reasonably easy to manage.

If you have additional thoughts on the matter, I love to read them, so please don’t fail to express yourself for us all.

I am an honest freak (or reasonably responsibly balanced "misfit", if you prefer) of an artist working and resting to best carefully contribute towards helping society. Too many people abuse reasoning (e.g. 'partial truth = whole truth' scam), while I exercise reason to explore and express whole truth without any conflict-of-interest -- all within a sometimes offbeat style of psychedelic artistry.

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Posted in Respect Cannabis

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